From the Wuhan-Hu-1 strain to the XD and XE variants: is targeting the SARS-CoV-2 spike protein still a pharmaceutically relevant option against COVID-19?우한-Hu-1 변종에서 XD 및 XE 변종까지: SARS-CoV-2 스파이크 단백질을 표적으로 하는 것이 여전히 COVID-19에 대한 약학적으로 적절한 옵션입니까?Article Published on 2022-12-012022-09-11 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] COVID19(2023년), SARS, 변종, [키워드] contributing to COVID-19 COVID-19 pandemic death Efficacy feature glycoprotein hospitalisations infections milestone MPro Mutation mutations outbreak pandemic Paxlovid Protein reported SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variant spike Spike protein Surface glycoprotein the SARS-CoV-2 the SARS-CoV-2 genome the Spike Treatment Vaccines variant viral surface Wuhan-Hu-1 XD variant XE variant. [DOI] 10.1080/14756366.2022.2081847 PMC 바로가기 [Article Type] Article
The Drosophila melanogaster ACE2 ortholog genes are differently expressed in obesity/diabetes and aging models: Implications for COVID-19 pathologyArticle Published on 2022-12-012022-11-15 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 ACE2 ortholog ACE2 orthologs ACE2 receptor Acer age analyzed Ance animal model approach bind binding affinity complement coronavirus disease COVID-19 COVID-19 pathology COVID-19 severity death dependent on diabetes disorders Drosophila melanogaster Effect elderly ENhance expressed Factors glycoprotein host cells humans increase individual interact Interaction molecular molecular docking mRNA expression obesity ortholog predicted Protein regions regulated Research responsible risk factor Risk factors. robust SARS-CoV-2 SARS-CoV-2 variant shown spike spike-ACE2 susceptible the Spike translational Transmissibility virus [DOI] 10.1016/j.bbadis.2022.166551 PMC 바로가기
The spike gene target failure (SGTF) genomic signature is highly accurate for the identification of Alpha and Omicron SARS-CoV-2 variantsArticle Published on 2022-11-082022-11-15 Journal: Scientific Reports [Category] SARS, 변종, 유전자 메커니즘, 치료기술, 치료제, [키워드] 95% CI Accuracy Alpha variant Amino acid Analysis B.1.1.529 B.1.1.7 cause Del detect evaluated genomic Laboratory Mutation omicron positive Positive predictive value Protein resulting RT-PCR S gene SARS-CoV-2 SARS-CoV-2 RT-PCR SARS-CoV-2 variant Sensitivity and specificity sequenced Sequencing spike gene TaqPath tested the Spike Thermo Fisher variant variants of concern VoC [DOI] 10.1038/s41598-022-21564-y PMC 바로가기
Modeling studies on the role of vitamins B1 (thiamin), B3 (nicotinamide), B6 (pyridoxamine), and caffeine as potential leads for the drug design against COVID-19Article Published on 2022-11-072022-11-15 Journal: Journal of molecular modeling [Category] SARS, 신약개발, 치료제, [키워드] ACE-2 adopted Antiviral antiviral activity applied approach binding pocket binding site caffeine Cell Characteristics chemical property Compound COVID-19 COVID-19 pandemic docking domain dosage drug design effective evaluate function impair Interaction Invasion lack mechanism modeling molecular molecular dynamic simulations Neutral nicotinamide potential mechanism Protein pyridoxamine Safe SARS-CoV-2 selected Side effects Structural analysis Structure the SARS-CoV-2 the Spike thiamin Toxicity Vitamin Vitamin B. [DOI] 10.1007/s00894-022-05356-9 PMC 바로가기
A subunit vaccine candidate based on the Spike protein of SARS-CoV-2 prevents infectious virus shedding in catsSARS-CoV-2의 스파이크 단백질을 기반으로 하는 서브유닛 백신 후보는 고양이의 감염성 바이러스 발산을 방지합니다Article Published on 2022-11-012022-09-11 Journal: Research in veterinary science [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] affected cats demonstrated described effective human infection Infection Infectious virus Neutralizing antibody response occurred Oropharyngeal Population Prevent preventive measure preventive measures produced Protein rectal swab SARS-CoV-2 SARS-CoV-2 virus spike Spike protein submitted subunit Subunit vaccine Subunit vaccine. susceptible the disease the SARS-CoV-2 virus the Spike Transmission Trial triggered vaccination Vaccine vaccine candidate Viral viral infection virus [DOI] 10.1016/j.rvsc.2022.05.003 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Omicron Variant of Concern: Everything You Wanted to Know about Omicron but Were Afraid to AskArticle Published on 2022-11-012022-11-15 Journal: Yonsei medical journal [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome booster coronavirus COVID-19 disease severity Diseases domain effective Effectiveness Epidemiology evade genetics immune response increase in Infection less monoclonal antibody morbidity and mortality mutated Mutation omicron Omicron variant pandemic Protein reported SARS-CoV-2 Spread the Spike Transmissibility Treatment Vaccine variant Variant of concern. variants virus virus [DOI] 10.3349/ymj.2022.0383 PMC 바로가기
Reduced Sensitivity of Commercial Spike-Specific Antibody Assays after Primary Infection with the SARS-CoV-2 Omicron VariantArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] addition Affect analyzed anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibodies antibody antibody assay Antibody assays antigenic antigenic structure antigens assays change changes in characterized controls convalescent individual correlation diagnostic immunoassay immunoassays immunoreactivity impairing individual Infection lack neutralization Neutralization assay Neutralizing activity Neutralizing antibodies Neutralizing antibody titer omicron Primary infection Protein quantified RBD reduced SARS-CoV-2 SARS-CoV-2-specific antibody sensitivity significantly spike statistically significant reduction subjects surrogate assay. tested the SARS-CoV-2 the Spike variant variants were used wild type wild-type wild-type strain [DOI] 10.1128/spectrum.02129-22 PMC 바로가기
Hybrid Immunity Shifts the Fc-Effector Quality of SARS-CoV-2 mRNA Vaccine-Induced ImmunityArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] accelerate antibody antibody function Antibody Response Antibody titer Antigen binding antibody Combination comparable conserved COVID-19 cross-reactivity disease dose expected Fc-receptors first dose function functional functions humoral immune response hybrid Hybrid immunity immune immune priming Immunity immunization immunodominance increases in indicate individual individuals Infection magnitude modify mRNA mRNA vaccination mRNA vaccine mRNA vaccines neutralizing antibody offer Quality receive recent Region remained resulting robust SARS-CoV-2 second dose selective serology shift spike subsequent symptomatic T cell the SARS-CoV-2 the Spike unique vaccination Vaccine vaccine-induced immune response vaccinee Vaccines Vaccines. variants of concern virus while [DOI] 10.1128/mbio.01647-22 PMC 바로가기
Dual Monoclonal Antibodies on Sars-Cov-2 Alpha and Delta Variants: Clinical and Virological EfficacyArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, 치료제, [키워드] analysis antibodies antibody antiviral efficacy association bamlanivimab/etesevimab casirivimab/imdevimab clinical conducted Course COVID-19 Delta Dual therapy Efficacy France genomic glycoprotein growth high risk highlight joint management monoclonal monoclonal antibodies monoclonal antibody Mutation mutation selection. neutralization omicron overlap Paris Patient patients died patients treated Prevent Protein resistance mechanism SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 variant SARS-CoV-2-positive patients selected selective severe COVID-19 spike Spread the Spike therapy treat Treatment treatment initiation variant variants viral genome Viral load viral mutation was done [DOI] 10.1128/spectrum.02152-22 PMC 바로가기
Towards the development of an epitope-focused vaccine for SARS-CoV-2Article Published on 2022-10-262022-11-15 Journal: Vaccine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibodies BALB/c mice CD8+ T cell COVID-19 deficiency disease DNA effective effort epitope expression hamster hamsters IFN-γ immunogenic immunogenicity data in vitro Inclusion mice Mortality pandemic coronavirus peptide peptides platform predicted prevalent Protein Proteins RBD peptide regions reported RNA Safe SARS-CoV-2 SARS-CoV-2 virus sequence specific IgG antibody spread of COVID-19 starting point subcutaneous administration Support tested the Spike Vaccine Vaccine development vaccine. Vaccines variant variants of concern Viral vector virus [DOI] 10.1016/j.vaccine.2022.09.059 PMC 바로가기